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oai:mountainscholar.org:10217/837572025-12-30T03:24:43Zcom_10217_100532com_10217_100000com_10217_100470com_10217_100303col_10217_100538col_10217_100472

Leszczak, Victoria, author Popat, Ketul C., advisor Reynolds, Melissa, committee member Dasi, Prasad, committee member Williams, John, committee member 2007-01-03T06:32:03Z 2007-01-03T06:32:03Z 2014 Leszczak_colostate_0053A_12613.pdf http://hdl.handle.net/10217/83757 https://doi.org/10.25675/3.018579 Cardiovascular disease is the leading killer of people worldwide. Current treatments include organ transplants, surgery, metabolic products and mechanical/synthetic implants. Of these, mechanical and synthetic implants are the most promising. However, rejection of cardiovascular implants continues to be a problem, eliciting a need for understanding the mechanisms behind tissue-material interaction. Recently, bioartificial implants, consisting of synthetic tissue engineering scaffolds and cells, have shown great promise for cardiovascular repair. An ideal cardiovascular implant surface must be capable of adhering cells and providing appropriate physiological responses while the native tissue integrates with the scaffold. However, the success of these implants is not only dependent on tissue integration but also hemocompatibility (interaction of material with blood components), a property that depends on the surface of the material. A thorough understanding of the interaction of cardiovascular cells and whole blood and its components with the material surface is essential in order to have a successful application which promotes healing as well as native tissue integration and regeneration. The purpose of this research is to study polymeric nanowire surfaces as potential interfaces for cardiovascular applications by investigating cellular response as well as hemocompatibility. born digital doctoral dissertations English eng Colorado State University. Libraries 2000-2019 Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright. endothelial cells hemocompatibility nanowires platelets polycaprolactone smooth muscle cells Polycaprolactone nanowire surfaces as interfaces for cardiovascular applications Text Doctor of Philosophy (Ph.D.) Doctoral Mechanical Engineering Colorado State University This Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). open.access