2026-09-21T11:52:31Zhttps://api.mountainscholar.org/server/oai/request

oai:mountainscholar.org:10217/716012025-12-30T03:23:28Zcom_10217_100532com_10217_100000com_10217_100367com_10217_100303col_10217_100538col_10217_100368

Welch, Timothy R., author Williams, Robert M., advisor Rovis, Tomislav, committee member Wood, John L., committee member Ackerson, Chris, committee member Thamm, Douglas H., committee member 2007-01-03T08:26:29Z 2014-01-01T08:10:42Z 2012 Welch_colostate_0053A_11366.pdf ETDF2012500342CHEM http://hdl.handle.net/10217/71601 https://doi.org/10.25675/3.018544 This dissertation documents efforts toward the asymmetric total syntheses of the natural products (+)-chetomin and (-)-sporidesmin A. Synthetic methods have been developed to efficiently construct the dioxopiperazine core of both molecules. Additionally, a simple epidithiodioxopiperazine has been synthesized to demonstrate a general method for the addition of a sulfur bridge to a dioxopiperazine ring. The work described herein, while not totally successful, provides a basis for future completion of the asymmetric total syntheses of these two epidithiodioxopiperazines and other related fungal metabolites. born digital doctoral dissertations English eng Colorado State University. Libraries 2000-2019 Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright. Epidithiodioxopiperazines: synthetic studies of (+)-chetomin and (-)-sporidesmin A Text 2014-01-01 2014-01-01 This Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). Doctor of Philosophy (Ph.D.) Doctoral Chemistry Colorado State University open.access