2026-09-21T22:29:12Zhttps://api.mountainscholar.org/server/oai/requestoai:mountainscholar.org:10217/2358592025-12-30T03:32:16Zcom_10217_100532com_10217_100000com_10217_100367com_10217_100303col_10217_100538col_10217_100368
Kosogof, Christi, author
Williams, Robert M., advisor
2022-11-28T17:46:49Z
2022-11-28T17:46:49Z
2001
https://hdl.handle.net/10217/235859
https://doi.org/10.25675/3.018777
DNA cross-linking agents represent one of the most potent categories of antitumor agents. Pyrrolizidine alkaloids are an abundant class of biologically active natural products. These alkaloids display high levels of DNA cross-linking ability, and could have potential use as antitumor agents. Unfortunately, the high levels of hepatotoxicity induced by these compounds negates their effectiveness as antitumor agents. Modification of the chemical structure of the pyrrolizidine core could yield compounds with potent antitumor activity and reduced hepatotoxicity. The synthesis of a class of potential pyrrolizidine progenitors developed from monocrotaline is discussed. The synthesis of a potential water soluble photolabile protecting group is also described. In addition, the biological evaluation of the synthesized pyrrolizidine progenitors was investigated.
masters theses
English
eng
Colorado State University. Libraries
Catalog record number (MMS ID): 991013435309703361
RS431.A64K67 2001
2000-2019
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Pyrrolizidines
Antineoplastic agents
Synthesis and biological evaluation of potential DNA cross-linking agents based on pyrrolizidine alkaloids
Text
Master of Science (M.S.)
Masters
Chemistry
Colorado State University
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open.access