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oai:mountainscholar.org:10217/2358582025-12-30T03:29:39Zcom_10217_100532com_10217_100000com_10217_100367com_10217_100303col_10217_100538col_10217_100368

Newkirk, Tenaya L., author Williams, Robert M., advisor Stermitz, Frank R., committee member Ferreira, Eric M., committee member Rickey, Dawn, committee member Thamm, Douglas H., committee member 2022-11-28T17:46:48Z 2022-11-28T17:46:48Z 2009 https://hdl.handle.net/10217/235858 https://doi.org/10.25675/3.018711 Herein are documented our efforts in two projects, beginning with studies towards the total synthesis of 14-acetoxygelsenicine. We have developed different strategies towards this complex natural product, wherein we have developed routes towards an appropriate substrate for a novel, intramolecular hetero Diels-Alder cyclization. The developed route would also lead to related members of this family of alkaloids, and helps set the stage for future efforts. In the second project discussed, we have successfully pursued the synthesis of numerous, biologically active analogs of the natural product (+)-largazole. Synthetic efforts have led to the design of inhibitors with unprecedented biological activity, as well as providing information regarding the structure-activity relationship of these molecules. doctoral dissertations English eng Colorado State University. Libraries Catalog record number (MMS ID): 991011773169703361 QD421.N485 2009 2000-2019 Copyright and other restrictions may apply. User is responsible for compliance with all applicable laws. For information about copyright law, please see https://libguides.colostate.edu/copyright. Alkaloids -- Synthesis Diels-Alder reaction Towards the total synthesis of 14-acetoxygelsenicine and synthesis of largazole analogs Text Doctor of Philosophy (Ph.D.) Doctoral Chemistry Colorado State University This Item is protected by copyright and/or related rights (https://rightsstatements.org/vocab/InC/1.0/). You are free to use this Item in any way that is permitted by the copyright and related rights legislation that applies to your use. For other uses you need to obtain permission from the rights-holder(s). open.access